Kwai shine farkon rayuwar ɗan adam, ƙwayar ƙwai ce da ba ta kai ba wadda daga ƙarshe ke girma ta zama ƙwai. Duk da haka, ingancin kwai yana raguwa yayin da mata ke tsufa ko kuma saboda wasu abubuwa kamar kiba, kuma ƙarancin ƙwayoyin oysters masu inganci sune babban dalilin ƙarancin haihuwa ga mata masu kiba. Duk da haka, yadda ake inganta ingancin ƙwayoyin oysters a cikin mata masu kiba ƙalubale ne ga masana kimiyya.
Kwanan nan, wani bincike mai taken Gudanar da nicotinamide mononucleotide yana inganta ingancin ƙwayoyin cuta na beraye masu kiba a cikin yaduwar ƙwayoyin halitta. Binciken ya gano cewa ƙarin sinadarin nicotinamide adenine dinucleotide (NAD+) precursornicotinamide mononucleosideAcid (NMN) zai iya inganta kumburin kwai, inganta ingancin ƙashi da kuma dawo da nauyin jikin 'ya'yan beraye masu kiba.
Masu binciken sun zaɓi beraye mata 'yan makonni 3 da beraye maza 'yan makonni 11 don kafa samfurin kiba ta beraye tare da abinci mai yawan kitse kuma an tabbatar da shi ta hanyar rikodin nauyi, gwajin glucose na jini na azumi, da gwajin haƙurin glucose na baki, da kuma maganin abinci 1 Na tsawon makonni 2,NMNAn yi wa kari allura na tsawon kwanaki 10 a jere domin gano bayyanar kwayoyin halittar da ke da alaƙa da ci gaban kwai da kuma kwayoyin halittar da ke da alaƙa da kumburi, girman kitse na kyallen ciki, matakin oocytes na oocytes, tsarin spindlechromosome, aikin mitochondrial, actin dynamics, da lalacewar DNA, idan aka kwatanta da sakamakon kididdiga da ke nuna:
1. An yi nasarar kafa wani samfurin beraye da ke ɗauke da kiba mai yawa a cikin abincin da ke ɗauke da kiba.
Darajar FGB ta ƙungiyar abinci mai yawan kitse (HFD) ta fi ta ƙungiyar abinci ta yau da kullun (ND), ban da haka, sakamakon OGTT ya nuna cewa ƙungiyar beraye masu yawan kitse (HFD) ba sa jure wa glucose.
2. NMN na iya inganta matsalolin rayuwa a cikin berayen HFD
Ƙarin tare daNMNKarin abinci ya rage yawan kitse a cikin beraye a cikin rukunin abinci mai yawan kitse (HFD), kuma sakamakon ya nuna cewa NMN yana da tasirin kariya akan rashin daidaituwar metabolism a cikin beraye a cikin rukunin abinci mai yawan kitse (HFD).
3. NMN yana inganta ingancin ƙwayar ƙwai a cikin beraye na HFD
NMN na iya inganta ingancin ƙwayar ƙwai a cikin beraye masu yawan kitse (HFD) ta hanyar daidaita bayyanar manyan kwayoyin halitta da suka shafi ci gaban ƙwayoyin ƙwai (Bmp4, Lhx8) da kumburi.
4. NMN yana rage lahani a cikin rarrabawar ulcers da lalacewar DNA a cikin beraye na HFD
NMN na iya rage yawan lahani na spindle da rashin daidaiton chromosome da abinci mai yawan kitse ke haifarwa (HFD), rage siginar γH2A.X, da kuma rage lalacewar DNA da abinci mai yawan kitse ke haifarwa ta hanyar rage bayyanar Bax.
5. NMN na iya inganta ingancin ƙwayoyin halitta
NMN na iya gyara yadda SOD1 mai hana tsufa ke aiki a cikin rukunin abinci mai yawan kitse (HFD), inganta rarrabawar mitochondria, kuma yana iya inganta ingancin oocytes ta hanyar kiyaye amincin cytoskeleton.
6. NMN na iya dawo da rarrabawar ɗigon lipid a cikin berayen HFD
Abincin da ke ɗauke da kitse mai yawa (HFD) ya ɗan fi na sauran ƙwayoyin halittar da ke ɗauke da kitse a cikin abinci na yau da kullun (ND), kuma ƙarin NMN zai iya rage ƙarfin hasken lipid.
7. NMN tana dawo da nauyin jiki a cikin zuriyar beraye na HFD
Nauyin haihuwar 'ya'yan ƙungiyar masu yawan kitse (HFD) ya yi ƙasa sosai da na ƙungiyar abinci ta yau da kullun (ND), kuma ƙarin abinci mai gina jiki tare da ƙarin abinci mai gina jiki (NMN) ya dawo da nauyin haihuwar 'ya'yan ƙungiyar HFD.
A cikin wannan binciken, masu bincike sun nuna ta hanyar gwaje-gwajen beraye cewa NMN tana da ikon inganta ingancin oocytes a cikin beraye mata masu kiba waɗanda abinci mai yawan kitse ke haifarwa, kuma sun bayyana cewa NMN na iya dawo da aikin mitochondrial da rage tarin ROS a cikin oocytes na berayen mata masu kiba., lalacewar DNA da kuma hanyoyin rarraba ɗigon lipid. Saboda haka, wannan binciken zai samar da dabarun magani mai yuwuwa don inganta matsalolin haihuwa da kiba ke haifarwa a cikin mata.
nassoshi:
1.Wang L, Chen Y, Wei J, da sauransu. Yin amfani da nicotinamide mononucleotide yana inganta ingancin ƙwayoyin halitta na beraye masu kiba. Tsarin ƙwayoyin halitta. 2022; e13303. doi10. 1111cpr.13303
Lokacin Saƙo: Satumba-28-2022