Oocyte shine farkon rayuwar dan adam, kwayar kwai ne da bai balaga ba wanda a karshe ya balaga ya zama kwai.Duk da haka, ingancin oocyte yana raguwa yayin da mata suka tsufa ko kuma saboda dalilai kamar kiba , kuma ƙananan oocytes sune babban dalilin rashin haihuwa a cikin mata masu kiba.Duk da haka, yadda za a inganta ingancin oocytes a cikin mata masu kiba kalubale ne ga masana kimiyya.
Kwanan nan , wani binciken mai suna Gudanarwa na nicotinamide mononucleotide yana inganta ingancin oocyte na mice masu kiba da aka buga a cikin yaduwar kwayar halitta.Binciken ya gano cewa kari na nicotinamide adenine dinucleotide (NAD+) precursornicotinamide mononucleosideAcid (NMN) na iya inganta haɓakar kumburin ovarian yadda ya kamata, haɓaka ingancin oocyte da dawo da nauyin jikin ɗan adam a cikin ɓerayen mata masu kiba.
Masu binciken sun zaɓi berayen mata masu sati 3 da ɓeraye maza masu sati 11 don kafa samfurin linzamin kwamfuta na kiba tare da abinci mai kitse kuma an inganta su ta hanyar rikodin nauyi, gwajin glucose na jini mai azumi, da gwajin haƙuri na glucose na baka, sa baki na abinci. 1 Tsawon sati 2,NMNkari da aka allura for 10 jere kwanaki don gane da ovarian ci gaban da alaka da kwayoyin halitta da kumburi da alaka da kwayoyin, kitsen size na ciki adipose nama, amsa oxygen jinsunan matakin oocytes, spindlechromosome tsarin, mitochondrial Function, actin kuzarin kawo cikas, da DNA lalacewa. idan aka kwatanta da sakamakon kididdiga da ke nuna:
1. An samu nasarar kafa samfurin linzamin kwamfuta mai kiba mai kiba
Ƙimar FGB na ƙungiyar abinci mai kitse (HFD) ta kasance koyaushe sama da na rukunin abinci na yau da kullun (ND), bugu da ƙari, sakamakon OGTT ya nuna cewa rukunin berayen abinci mai kitse (HFD) ba su jure wa glucose.
2. NMN na iya inganta rashin daidaituwa na rayuwa a cikin berayen HFD
Kariwa daNMNkari ya rage yawan kitse a cikin beraye a cikin rukunin abinci mai kitse (HFD), kuma sakamakon ya nuna cewa NMN yana da tasirin kariya akan rashin daidaituwar metabolism a cikin mice a cikin rukunin abinci mai-mai yawa (HFD).
3. NMN yana inganta ingancin ovarian a cikin berayen HFD
NMN na iya inganta ingancin ovarian a cikin abinci mai girma (HFD) mice ta hanyar daidaita maganganun kwayoyin halitta masu mahimmanci da suka danganci ci gaban ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta (Bmp4, Lhx8) da kumburi.
4. NMN yana rage lahani na rarraba oocyte da lalacewar DNA a cikin berayen HFD
NMN na iya rage yawan yawan lahani na spindle da chromosomal misconciment lalacewa ta hanyar abinci mai-mai yawa ( HFD ) , rage siginar γH2A.X, da inganta ingantaccen abinci mai kitse (HFD) - jawo lalacewar DNA ta hanyar rage bayyanar Bax.
5. NMN na iya inganta ingancin oocytes
NMN na iya gyara ƙayyadaddun ƙayyadaddun maganganun SOD1 na antioxidant a cikin ƙungiyar abinci mai girma (HFD), inganta rarraba mitochondria, kuma zai iya inganta ingancin oocytes ta hanyar kiyaye mutuncin cytoskeleton.
6. NMN na iya dawo da rarraba digon lipid a cikin berayen HFD
Abincin mai mai yawa (HFD) rukunin oocytes sun ɗan fi girma fiye da na a cikin abinci na al'ada (ND) ƙungiyar oocytes, kuma ƙarin NMN zai iya rage girman haske na ɗigon lipid.
7. NMN yana dawo da nauyin jiki a cikin zuriyar berayen HFD
nauyin haihuwa na 'ya'yan ƙungiyar abinci mai kitse (HFD) ya ragu sosai fiye da na rukunin abinci na yau da kullun (ND), kuma kari tare da ƙarin NMN ya dawo da nauyin haihuwar zuriyar ƙungiyar HFD.
A cikin wannan binciken, masu bincike sun nuna ta hanyar gwaje-gwajen linzamin kwamfuta cewa NMN yana da ikon inganta ingancin oocytes a cikin ƙwanƙwasa mata masu kiba da aka haifar da abinci mai yawan gaske, kuma sun bayyana cewa NMN zai iya mayar da aikin mitochondrial kuma ya rage yawan ROS a cikin oocytes na mata masu kiba., Lalacewar DNA da hanyoyin da ke da tushe na rarraba digon lipid.Don haka, wannan binciken zai ba da damar dabarun warkewa don inganta matsalolin haihuwa da ke haifar da kiba a cikin mata.
nassoshi:
1.Wang L, Chen Y, Wei J, et al.Gudanar da nicotinamide mononucleotide yana inganta ingancin oocyte na mice masu kiba.Cell Prolif.2022;ku 13303.doi10.1111cpr.13303
Lokacin aikawa: Satumba-28-2022