NMN yana rage fibrosis na hanji wanda ke haifar da radiation ta hanyar daidaita microbiota.

Fibrosis na hanji da ke haifar da radiation shine matsala ta gama gari na waɗanda suka tsira na dogon lokaci bayan aikin rediyo na ciki da ƙwanƙwasa.A halin yanzu, babu wata hanyar asibiti da za a bi don magance fibrosis na hanji da ke haifar da radiation.Nazarin ya nuna cewa nicotinamide mononucleotide (NMN) yana da yuwuwar daidaita flora na hanji.Furen hanji wata cuta ce ta al'ada a cikin hanjin ɗan adam, wanda zai iya haɗa nau'ikan sinadirai masu mahimmanci don haɓakar ɗan adam da haɓaka.Da zarar flora na hanji ya fita daga daidaito, zai haifar da cututtuka iri-iri.
Kwanan nan, Cibiyar Nazarin Kiwon Lafiya ta kasar Sin da Kwalejin Kiwon Lafiya ta Peking Union ta buga sakamakon bincike a cikin mujallar International Journal of Radiation Biology, wanda ya nuna cewa NMN na iya rage fibrosis na hanji da radiation ke haifarwa ta hanyar daidaita flora na hanji.
Da farko, ƙungiyar bincike ta raba berayen zuwa ƙungiyar kulawa, ƙungiyar NMN, ƙungiyar IR da ƙungiyar NMNIR, kuma sun ba 15 Gy irradiation na ciki ga ƙungiyar IR da ƙungiyar NMNIR.A halin yanzu, an ba da ƙarin NMN ga ƙungiyar NMN da ƙungiyar NMNIR a kashi na yau da kullum na 300mg/kg.Bayan shan shi na wani ɗan lokaci, ta hanyar gano ƙwayoyin linzamin kwamfuta, microflora na hanji da alamun nama na hanji, sakamakon kwatancen ya nuna cewa:

1. NMN na iya gyara abun da ke ciki da aikin flora na hanji wanda ke damun radiation.
Ta hanyar kwatanta gano flora na hanji tsakanin rukunin IR da ƙungiyar NMNIR, an gano cewa ƙungiyar IR ta ƙara yawan flora na hanji masu cutarwa, kamar Lactobacillus du, Bacillus faecalis, da sauransu. da kuma kara yawan flora na hanji masu amfani, kamar kwayoyin AKK, ta hanyar kara NMN.Gwaje-gwaje sun nuna cewa NMN na iya gyara abun da ke ciki da aikin flora na hanji wanda ba shi da ma'auni saboda radiation.

2. NMN yana rage fibrosis na hanji wanda radiation ya haifar
Matsayin aSMA (Fibrosis Marker) a cikin berayen da aka fallasa ga radiation ya ƙaru sosai.Bayan kariyar NMN, ba kawai matakin alamar alamar aSMA ya ragu sosai ba, har ma da TGF-b mai kumburi wanda ke inganta fibrosis na hanji ya ragu sosai, yana nuna cewa NMN kari zai iya rage fibrosis na hanji wanda radiation ya haifar.

(Hoto na 1. Maganin NMN yana rage fibrosis na hanji wanda radiation ya haifar)

Ƙarƙashin tushen yaduwar samfuran lantarki, radiation yana ƙara tasiri ga aikin mutane da rayuwa, musamman a kan tsire-tsire na hanji na dogon lokaci.NMN yana da tasirin kariya mai ƙarfi akan lafiyar hanji.Wannan tasirin ba wai kawai an gane shi ta hanyar abu ɗaya ko wata hanya ba, har ma ta hanyar daidaita tsarin rarraba flora don inganta kwanciyar hankali na aikin hanji daga kusurwoyi da kwatance daban-daban, wanda kuma yana ba da mahimmanci ga fa'idodi daban-daban na NMN.

Magana:
Xiaotong Zhao, Kaihua Ji, Manman Zhang, Hao Huang, Feng Wang, Yang Liu & Qiang Liu (2022)