Clenbuterol, shi ne β2-adrenergic agonist (β2-adrenergic agonist), kama da ephedrine (Ephedrine), ana amfani da shi sau da yawa a asibiti don magance cututtukan huhu na huhu (COPD), Hakanan ana amfani dashi azaman bronchodilator don sauƙaƙa matsananciyar exacerbations na asma.A farkon 1980s, wani kamfani na Amurka Cyanamid bisa kuskure ya gano cewa yana da tasirin gaske na haɓaka girma, inganta ƙimar nama mara kyau da rage kitse, don haka ana amfani da shi azaman clenbuterol a kiwon dabbobi.Duk da haka, saboda illolinsa, Ƙungiyar Turai ta haramta amfani da clenbuterol a matsayin abincin abinci tun ranar 1 ga Janairu, 1988. FDA ta haramta shi a 1991. A 1997, Ma'aikatar Noma ta Jamhuriyar Jama'ar Sin ta haramtawa sosai. amfani da beta-adrenergic hormones a abinci da kuma samar da kiwon dabbobi, da kuma Clenbuterol hydrochloride ranked farko.
Duk da haka, Clenbuterol racemic kwanan nan an nuna don rage haɗarin cutar Parkinson.Don tabbatar da abin da (ko duka) isomers samar da wannan sakamako, da tsarki Clenbuterol enantiomer bukatar a yi karatu daban.
A cikin wani labarin kwanan nan, ƙungiyar bincike ta Elisabeth Egholm Jacobsen na Sashen Kimiyyar Kimiyya, Jami'ar Kimiyya da Fasaha ta Norwegian, tare da haɗin gwiwar Dr. Zhu Wei na Shangke Bio, ya haifar da kira na ketoreductase KRED da cofactor nicotinamide adenine dinucleoside phosphate (NADPH). ).(R) -1- (4-Amino-3,5-dichlorophenyl) -2-bromoethan-1-ol, ee> 93%;da (S) -N- (2 an haɗa su ta hanyar tsarin guda ɗaya, 6-Dichloro-4- (1-hydroxyethyl) phenyl) acetamide, ee> 98%.Dukansu masu tsaka-tsakin da ke sama sune yuwuwar abubuwan da suka faru na clenbuterol isomers.Ketoreductase ES-KRED-228 da aka yi amfani da shi a cikin wannan binciken ya fito ne daga Shangke Biopharmaceutical (Shanghai) Co., Ltd. Sakamakon binciken "Chemoenzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol da sauran -2-Agonists" an buga shi a cikin "Catalysts" akan. Nuwamba 4, 2018.
Lokacin aikawa: Agusta-26-2022