Hypopigmentation cuta ce ta fata, galibi tana bayyana ta raguwar melanin.Alamomin gama gari sun haɗa da vitiligo, albinism da hypopigmentation bayan kumburin fata.A halin yanzu, babban maganin hypopigmentation shine maganin baka, amma maganin baka zai haifar da atrophy na fata, rashin jin daɗi na ciki da sauran lahani.Sabili da haka, wajibi ne don haɓaka abu na halitta ba tare da sakamako masu illa ba don magance hypopigmentation.
Kwanan nan, Rahoton Kimiyya ya buga labarin mai suna "Bincike na yau da kullun yana nuna yuwuwar spermidine don maganin hypopigmentation | ta hanyar daidaita furotin da ke hade da melanogenesis".Sakamakon ya nuna cewa spermidine za a iya bi da shi ta hanyar ƙarfafa sunadarai masu alaƙa da melanogenesis.hypopigmentation.
一, Maganin Spermidine yana ƙara samar da melanin
Don yin nazarin tasirin spermidine akan samar da melanin, ƙungiyar bincike sun bi da melanin a cikin ƙwayoyin MNT-1 tare da nau'i daban-daban na spermidine.Ta hanyar ƙididdige ƙididdiga, an gano cewa maganin spermidine yana ƙara samar da melanin.
Spermidine na iya tsara tsarin lalata sunadaran da ke da alaƙa da melanogenesis
Don tabbatar da cewa spermidine na iya daidaita kwayoyin halittar da ke cikin lalata sunadaran gina jiki, ƙungiyar bincike ta gano 181 genes da aka tsara da kuma 82 genes sama da aka tsara ta hanyar gano kwayoyin da aka yi wa spermidine, ban da kwayoyin da ke da alaka da melanogenesis.Don ƙarin tabbatarwa, ƙungiyar binciken sun bincika tasirin spermidine akan matakin furci na dangin tyrosinase na dangin TYR, TRP-1 da TRP-2, waɗanda kwayoyin halitta ne da ke daidaita samar da melanin.Matsayin magana na mRNA ya tabbatar da cewa spermidine bai canza bayanin kwayoyin da ke da alaka da melanogenesis ba.Duk da haka, aikin kwayoyin halitta da yawa yana canzawa ta hanyar spermidine kuma yana da alaka da lalatawar furotin.Yawancin ƙwayoyin halittar da aka canza suna da alaƙa da ko'ina, wanda shine tsarin lalata furotin da ke da alaƙa da melanogenesis.
Spermidine yana daidaita daidaiton sunadaran kuma yana haɓaka samar da melanin.
Ana sarrafa samar da melanin ta hanyar ma'auni na kira da lalata ƙwayoyin sunadarai masu alaka da melanin.Spermidine yana maganin kwayoyin TYR, TRP-1 da TRP-2.Ta hanyar aikin jigilar jigilar kwayoyin halitta SLC3A2, SLC7A1, SLC18B1 da SLC22A18, zai iya ƙara yawan matakan polyamines a cikin sel, don haka ƙara kwanciyar hankali na sunadaran da ke da alaka da samar da melanin don inganta samar da melanin a cikin vivo.
A ƙarshe, wannan binciken ya nuna cewa maniyyi na halitta yana da tasiri mai mahimmanci wajen maganin hypopigmentation, kuma yana da wasu darajar aikace-aikace a fannin kayan shafawa da kayan kiwon lafiya a nan gaba.
Magana:
[1].Brito, S., Heo, H., Cha, B. et al.Binciken na yau da kullun yana nuna yuwuwar spermidine don maganin hypopigmentation ta hanyar daidaitawar sunadaran da ke hade da melanogenesis.Sci Rep 12, 14478 (2022).doi.org/10.1038/s41598-022-18629-3.
Lokacin aikawa: Satumba-28-2022