Hypopigmentation cuta ce ta fata, wadda galibi ke bayyana ta hanyar rage yawan melanin. Alamomin da aka fi sani sun haɗa da vitiligo, albinism da hypopigmentation bayan kumburin fata. A halin yanzu, babban maganin hypopigmentation shine maganin baki, amma maganin baki zai haifar da bushewar fata, rashin jin daɗin ciki da sauran illoli. Saboda haka, ya zama dole a samar da wani abu na halitta wanda ba shi da illa don magance hypopigmentation.
Kwanan nan, Rahoton Kimiyya ya buga wani kasida mai taken "Bincike mai tsari ya bayyana yuwuwar spermidine don maganin hypopigmentation | ta hanyar daidaita sunadaran da ke da alaƙa da melanogenesis". Sakamakon ya nuna cewa ana iya magance spermidine ta hanyar daidaita sunadaran da ke da alaƙa da melanogenesis. hypopigmentation.
Maganin maniyyi yana ƙara samar da melanin
Domin yin nazarin tasirin spermidine akan samar da melanin, ƙungiyar binciken ta yi maganin melanin a cikin ƙwayoyin MNT-1 tare da yawan spermidine daban-daban. Ta hanyar nazarin adadi, an gano cewa maganin spermidine yana ƙara yawan samar da melanin.
Spermidine na iya daidaita tsarin lalata furotin da ke da alaƙa da melanogenesis
Domin tabbatar da cewa spermidine na iya daidaita kwayoyin halittar da ke da hannu a lalacewar furotin, ƙungiyar binciken ta gano kwayoyin halitta 181 da aka rage yawansu da kuma kwayoyin halitta 82 da aka daidaita ta hanyar gano ƙwayoyin halittar da aka yi wa magani da spermidine, ban da kwayoyin halittar da ke da alaƙa da melanogenesis. Don ƙarin tabbatarwa, ƙungiyar binciken ta yi nazarin tasirin spermidine akan matakin bayyanar dangin kwayar halittar tyrosinase TYR, TRP-1 da TRP-2, waɗanda kwayoyin halitta ne da ke daidaita samar da melanin. Matsayin bayyanar mRNA ya tabbatar da cewa spermidine bai canza bayyanar kwayoyin halittar da ke da alaƙa da melanogenesis ba. Duk da haka, ayyukan kwayoyin halitta da dama suna canzawa ta hanyar spermidine kuma suna da alaƙa da lalacewar furotin. Da yawa daga cikin kwayoyin halittar da aka canza suna da alaƙa da ubiquity, wanda tsarin lalata furotin ne da ke da alaƙa da melanogenesis.
Man shafawa yana daidaita daidaiton sunadaran kuma yana haɓaka samar da melanin.
Ana daidaita samar da melanin ta hanyar daidaita hadewar sunadaran da suka shafi melanin da kuma lalacewarsu. Spermidine yana magance kwayoyin halittar TYR, TRP-1 da TRP-2. Ta hanyar aikin kwayoyin halittar masu jigilar kaya SLC3A2, SLC7A1, SLC18B1 da SLC22A18, yana iya kara yawan polyamines a cikin kwayoyin halitta, ta haka yana kara daidaiton sunadaran da ke da alaƙa da samar da melanin don inganta samar da melanin a cikin jiki.
A ƙarshe, wannan binciken ya nuna cewa sinadarin spermidine na halitta yana da tasiri mai kyau wajen magance matsalar rashin haske, kuma yana da wani amfani a fannin kayan kwalliya da kayayyakin lafiya a nan gaba.
Nassoshi:
[1].Brito, S., Heo, H., Cha, B. da sauransu. Wani bincike mai tsari ya bayyana yuwuwar spermidine don maganin hypopigmentation ta hanyar daidaita sunadaran da ke da alaƙa da melanogenesis. Sci Rep 12, 14478 (2022). https://doi.org/10.1038/s41598-022-18629-3.
Lokacin Saƙo: Satumba-28-2022