β-Nicotinamide adenine dinucleotide (free acid) (NAD)
NAD shine coenzyme gama gari na dehydrogenase a cikin halittu masu rai.Yana shiga cikin halayen redox a cikin rayayyun halittu, kuma yana jigilarwa da canja wurin electrons don abubuwan da ke cikin halayen.Dehydrogenase yana taka muhimmiyar rawa a cikin metabolism na mutum.Wasu mahimman motsi na rayuwa na jikin ɗan adam, kamar lalatawar furotin, ruɓar carbohydrate, da bazuwar mai, ba za a iya aiwatar da su ta yau da kullun ba tare da dehydrogenase ba, kuma mutane za su rasa alamun mahimmanci.Kuma saboda haɗin NAD da dehydrogenase na iya haɓaka metabolism, don haka NAD wani ɓangare ne na jikin ɗan adam wanda babu makawa.Dangane da amfani da samfur, ana iya raba shi zuwa maki masu zuwa: darajar biotransformation, darajar reagent, ƙimar abinci na lafiya, API da albarkatun ƙasa.
| Sunan Sinadari | Nicotinamide adenine dinucleotide (free acid) |
| Makamantu | β-Nicotinamide adenine dinucleotide |
| Lambar CAS | 53-84-9 |
| Nauyin Kwayoyin Halitta | 663.43 |
| Tsarin kwayoyin halitta | Saukewa: C21H27N7O14P2 |
| EINECS ya hada da: | 200-184-4 |
| Wurin narkewa | 140-142 ° C (decomp) |
| yanayin ajiya. | -20°C |
| narkewa | H2O: 50 mg/ml |
| tsari | Foda |
| launi | Fari |
| Merck | 14,6344 |
| BRN | 3584133 |
| Kwanciyar hankali: | Barga.Hygroscopic.Wanda bai dace ba tare da magunguna masu ƙarfi masu ƙarfi. |
| InChiKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Gwajin Abun | Ƙayyadaddun bayanai |
| Bayyanar | Fari zuwa kashe-fari crystalline foda |
| UV spectral bincike ε260 nm da pH 7.5 | (18±1.0)×10³L/mol/cm |
| Solubility | 25mg/mL 25mg/mL a cikin ruwa |
| Abun ciki (ta hanyar bincike na enzymatic tare da ADH a pH 10, ta amfani da spectrophotometer, abs.340nm, akan tushen anhydrous) | ≥98.0% |
| Assay (ta HPLC, akan anhydrous tushen) | 98.0 ~ 102.0% |
| Tsarki (na HPLC, % yanki) | ≥99.0% |
| Abun ciki na ruwa (na KF) | ≤3% |
Kunshin:Bottle, Aluminum tsare jakar, 25kg / Kwali Drum, ko bisa ga abokin ciniki ta bukata.
Yanayin Ajiya:Ajiye tam a cikin duhu, don dogon ajiya a ajiye a 2 ~ 8 ℃.
Matsayin biotransformation: Ana iya amfani da shi don haɓakar biocatalytic na tsaka-tsakin magunguna da APIs, galibi tare da enzymes catalytic, kamar ketoreductase (KRED), nitroreductase (NTR), P450 monooxygenase (CYP), formate dehydrogenase (FDH)), glucose dehydrogenase (FDH) GDH), da sauransu, waɗanda zasu iya haɗa kai don canza matsakaicin amino acid daban-daban da sauran magunguna masu alaƙa.A halin yanzu, yawancin masana'antar harhada magunguna na cikin gida sun fara amfani da maye gurbin enzyme na halitta, kuma buƙatun kasuwa na NAD + yana haɓaka cikin sauri.
Matsayin bincike na reagent: Haɗe tare da nau'ikan enzymes na bincike, azaman ɗanyen kayan aikin bincike.
Matsayin abinci na lafiya: NAD shine coenzyme na dehydrogenase.Yana taka rawar da ba za a iya maye gurbinsa ba a cikin glycolysis, gluconeogenesis, sake zagayowar acid tricarboxylic, da sarkar numfashi, yana taka muhimmiyar rawa wajen samar da makamashi, kuma yana taimakawa wajen samar da L-dopa, wanda ya zama dopamine Neurotransmitters.Musamman ma a cikin 'yan shekarun nan, an gano cewa "injin" da "man fetur" a cikin aikin gyaran lalacewar kwayoyin halitta.Dangane da bincike, ƙarin abubuwan coenzymes (ciki har da NMN, NR, NAD, NADH) a cikin vitro na iya haɓaka ƙarfin antioxidant na ƙwayoyin nama, hana siginar apoptosis, dawo da aikin sel na al'ada, hana kamuwa da cuta ko hana ci gaban cuta.
Bugu da ƙari, coenzymes na iya haɓaka ƙarfin amsawar rigakafi ta hanyar kunnawa da inganta haɓakar ƙwayoyin rigakafi na asali, samar da abubuwan anti-mai kumburi da kuma kawar da tsarin kwayoyin T.Nicotinamide dinucleotide oxidation state (NAD +) wani coenzyme ne da aka samu a cikin dukkanin kwayoyin halitta.Yana taka muhimmiyar rawa a cikin ɗaruruwan matakai na rayuwa a cikin sel, yana shiga cikin dubban halayen ilimin lissafi, kuma shine mafi mahimmancin memba na sarkar jigilar lantarki.Mai ba da gudummawar hydrogen;A lokaci guda, coenzyme I yana aiki a matsayin kawai substrate na enzymes masu alaƙa a cikin jiki, yana taimakawa wajen kula da ayyukan enzymes.
Nicotinamide mononucleotide (NMN) shine mahallin farko na nicotinamide adenine dinucleotide oxidation state (NAD +), wanda ke da hannu a cikin haɗin NAD a cikin vivo.A cikin 2013, Farfesa David Sinclair na Makarantar Kiwon Lafiya ta Harvard ya gano cewa tare da tsufa, matakin furotin coenzyme I (NAD +) na cofactor na tsawon rai a cikin jiki yana ci gaba da raguwa, wanda ke haifar da raguwar aikin mitochondrial na “dynamo” ta tantanin halitta, yana haifar da tsufa. , da abubuwa daban-daban a cikin jiki.Ta haka ne ake haifar da rashin aikin irin wannan aikin.Dangane da jerin bincikensa, abubuwan da ke cikin NAD + a cikin jikin ɗan adam suna raguwa yayin shekaru, yana haifar da saurin tsufa daga shekaru 30, tare da wrinkles, shakatawa na tsoka, tara mai, da cututtuka kamar cututtukan zuciya, hawan jini, bugun jini. , ciwon sukari da cutar Alzheimer sun kara haɗari.Makullin tsawon rai shine haɓaka matakin coenzyme I (NAD +) a cikin jiki, haɓaka ƙimar ƙwayar sel, da haɓaka yuwuwar kuzarin kuruciya.
API da shirye-shiryen albarkatun kasa: Ana amfani da NAD + a cikin allurai don maganin jaraba na miyagun ƙwayoyi / sarrafawa, gami da NAD IV maganin jijiya da aka aiwatar a cikin Amurka, Turai, Rasha, Afirka ta Kudu, Mexico, Kudancin Amurka, kudu maso gabashin Asiya da sauran ƙasashe.Kayayyakin kantin magani da ya shirya da kansa, kama da na kantin Amurka, suna iya siyan kayan da za a rarraba su da kansu, kamar shirye-shiryen asibitocin kasar Sin, yana sarrafa ingancin kayan da kansa, da kuma shirya shirye-shirye a cikin magunguna.
