A cikin 'yan shekarun nan, tare da karuwar salon rayuwa mara kyau da kuma karuwar matsin lamba na zamantakewa na mata, yawan kamuwa da cutar polycystic ovary syndrome (PCOS) ya kara bayyana. Nazarin kasashen waje ya nuna cewa yawan kamuwa da cutar polycystic ovary syndrome (PCOS) a cikin mata masu shekaru haihuwa ya kai kashi 6% -15%, yayin da a China, adadin ya kai kashi 6% -10%.
Ciwon kwai na Polycystic cuta ce da ke faruwa a cikin mata masu haihuwa saboda matsalolin endocrine. Yana bayyana galibi a cikin rashin daidaituwar glucose da metabolism na lipid da kuma rashin aikin haihuwa. Sharuɗɗan ganewar asibiti sune matsalar matakin hormones (yawan androgen), raguwar ovulation da canje-canjen polycystic na kwai, kuma yawancin mata masu PC COS suna da mummunan halaye na metabolism, kamar juriya ga insulin, kiba, da steatosis na hanta.
A halin yanzu, akwai ƙananan magunguna don magance PCOS. Hanyar da aka saba amfani da ita ita ce inganta PCOS ta hanyar niyya da hana yawan androgen da magungunan anti-androgen. Duk da haka, akwai kuma shaidar cewa magungunan anti-androgen suna da guba mai ƙarfi a hanta, don haka amfaninsu yana da iyaka. Saboda haka, yana da matukar muhimmanci a nemi wani abu na halitta wanda ba shi da illa don maye gurbin magungunan da ake amfani da su a yanzu.
Wani bincike da Jami'ar New South Wales ta yi kwanan nan a Ostiraliya ya gano cewa cutar polycystic ovary syndrome tana da alaƙa da ƙarancin NAD+, kuma an buga sakamakon binciken a cikin mujallar kimiyya mai suna "Molecular Metabolism".
Ƙungiyar binciken ta fara dasa dihydrotestosterone (DHT) a cikin beraye mata kafin da kuma bayan balaga don kafa samfurin linzamin kwamfuta na PC COS, sannan bayan makonni 8 na maganin NMN, insulin na azumi da gano juriyar insulin na HOMA, gwajin haƙurin glucose, kitse Bayan gwaje-gwaje kamar histomorphometry, sakamakon ƙididdiga ya nuna:
1. N MN yana dawo da matakin N AD + a cikin tsokar berayen P COS
ya gano cewa matakin NAD+ a cikin tsokar beraye na PCOS ya ragu sosai, kuma an dawo da matakin NAD a cikin tsokar beraye na PCOS ta hanyar ciyar da NMN.
2. NMN yana inganta juriyar insulin da kiba a cikin berayen PCOS
Matakan insulin da DHT ke haifarwa sun ninka sau biyu a cikin berayen PCOS masu azumi, wanda wataƙila ke nuna juriyar insulin. Ta hanyar ciyar da NMN, an gano cewa matakin insulin na azumi ya dawo daidai da matakin berayen da suka saba. Bugu da ƙari, nauyin jikin berayen PCOS ya ƙaru da kashi 20%, kuma kitsen ya ƙaru sosai.
3. NMN yana dawo da ajiyar lipid na hanta mara kyau a cikin berayen PCOS
Ɗaya daga cikin halayen cutar polycystic ovary syndrome shine ajiyar lipids a cikin hanta da kuma haifar da hanta mai kitse. Bayan shan NMN, ajiyar lipids na hanta mara kyau a cikin berayen PCOS ya kusan ƙarewa, kuma triglycerides a cikin hanta sun koma matakin berayen da suka dace.
A ƙarshe, matakin NAD+ a cikin tsoka na PCOS ya ragu sosai, kuma yanayin PCOS ya ragu ta hanyar ƙara NMN, wanda shine farkon NAD+, wanda zai iya zama dabarun warkewa don maganin PCOS.
nassoshi:
[1]. Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA. Ragewar tsoka NAD+ a cikin hyperandrogenism Tsarin linzamin PCOS: Matsayi mai yuwuwa a cikin rashin daidaituwar metabolism. Mol Metab. 9 ga Satumba 2022;65:101583. doi: 10.1016/j.molmet.2022.101583. Epub kafin bugawa. PMID: 36096453.
Lokacin Saƙo: Nuwamba-17-2022