Metabolism na Molecular: Tasirin warkewa na ƙarin NMN akan ciwon ovary na polycystic

A cikin 'yan shekarun nan, tare da haɓakar salon rayuwa mara kyau da kuma karuwar matsalolin zamantakewar mata, yawan abin da ya faru na ciwon daji na polycystic ovary (PCOS) ya zama mafi bayyane.Binciken da aka yi a kasashen waje ya nuna cewa, yawan mace-macen mata da suka kai shekarun haihuwa (PCOS) ya kai kashi 6% -15 %, yayin da a kasar Sin, adadin ya kai kashi 6 -10%.

Polycystic ovary ciwo cuta ce da ke faruwa a cikin matan da suka kai shekarun haihuwa saboda cututtukan endocrine.An fi bayyana shi a cikin rashin daidaituwa na glucose da lipid metabolism da tabarbarewar haihuwa.Ma'auni na asibiti na asibiti shine rashin lafiyar matakin hormone (high androgen), dilute Ovulation disorders da ovarian polycystic canje-canje, kuma yawancin matan da ke da PC COS suna da siffofi masu ban sha'awa, irin su insulin juriya, kiba, da steatosis na hanta.

A halin yanzu, akwai 'yan magunguna don maganin PCOS.Hanyar gama gari ita ce inganta PCOS ta hanyar niyya da hana wuce haddi na androgen tare da magungunan anti-androgen.Duk da haka, akwai kuma shaida cewa magungunan anti-androgen suna da karfin hanta mai guba, don haka amfani da su yana da iyaka.Sabili da haka, yana da matukar muhimmanci a nemi abu na halitta ba tare da sakamako masu illa ba don maye gurbin kwayoyi na yanzu.

Binciken da Jami'ar New South Wales ta yi kwanan nan a Ostiraliya ya gano cewa ciwon ovary na polycystic yana da alaƙa da rashi NAD +, kuma an buga sakamakon binciken a cikin mujallar kimiyya "Molecular Metabolism".

Tawagar masu binciken sun fara dasa dihydrotestosterone (DHT) a cikin subcutaneously a cikin berayen mata kafin da bayan balaga don kafa samfurin linzamin kwamfuta na PC COS, sannan bayan makonni 8 na maganin NMN, insulin azumi da HOMA insulin juriya, gwajin haƙuri na glucose, mai Bayan gwaje-gwaje irin wannan. kamar yadda histomorphometry, sakamakon kididdiga ya nuna:

1. N MN yana mayar da matakin N AD + a cikin tsoka na P COS mice
An gano cewa matakin NAD + a cikin tsokar mice na PCOS ya ragu sosai, kuma an dawo da matakin NAD a cikin tsokar mice na PCOS ta ciyarwar NMN.

2. NMN yana inganta juriya na insulin da kiba a cikin mice PCOS
Matakan insulin da DHT ta haifar ya ninka fiye da ninki biyu a cikin berayen PCOS masu azumi, maiyuwa suna nuna juriya na insulin.Ta hanyar ciyar da NMN, an gano cewa an dawo da matakin insulin mai azumi zuwa matakin kusa da na ɓeraye na yau da kullun.Bugu da kari, nauyin jikin berayen PCOS ya karu da kashi 20%, kuma yawan kitse ya karu sosai.

3. NMN yana mayar da ma'aunin lipid na hanta mara kyau a cikin mice PCOS
Ɗaya daga cikin halayen ciwon ovary na polycystic shine ƙaddamar da lipid a cikin hanta da shigar da hanta mai kitse.Bayan shan nn, Lipors hanta hanta hanta an kusan cire shi, da kuma m a hanta sun dawo zuwa matakin mice na al'ada.

Ƙarshe, matakin NAD + a cikin tsoka na PCOS ya ragu sosai, kuma yanayin PCOS ya ragu ta hanyar ƙara NMN, wanda ya riga ya kasance na NAD +, wanda zai iya zama dabarun warkewa don maganin PCOS.

ambaton:
[1].Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA.Ragewar tsoka NAD + a cikin tsarin hyperandrogenism PCOS linzamin kwamfuta: Matsayi mai yuwuwa a cikin dysregulation na rayuwa.Mol Metab.2022 Satumba 9;65:101583.doi: 10.1016/j.molmet.2022.101583.Epub gaba da bugawa.Saukewa: 36096453.