Bincike Express |Nazarin Jami'ar Tsinghua ya nuna NMN na iya magance kumburi

Kunna Macrophage shine tsarin ƙwayoyin cuta wanda ke haifar da kumburi na yau da kullun a cikin jiki, amma kunnawar macrophage na yau da kullun na iya haifar da kumburi na yau da kullun da cututtuka irin su juriya na insulin da cututtuka masu tsanani kamar atherosclerosis.PGE 2, wanda ke ƙaddamar da amsawar ƙwayar cuta, an haɗa shi daga arachidonic acid ta hanyar cyclooxygenases (COX-1 da COX-2).COX-1 da COX-2 sune manyan makasudin maganin kumburi kuma ana iya hana su ta hanyar magungunan da ba steroidal anti-inflammatory (NSAIDs) ba.

Yin amfani da NSAIDs na iya haifar da mummunan halayen da yawa, kamar zubar jini na ciki .Sabili da haka, yana da mahimmanci musamman don nemo abu mafi aminci na halitta don magance kumburi.

Kwanan nan, ƙungiyar bincike daga Jami'ar Tsinghua ta yi amfani da macrophages na linzamin kwamfuta tare da NMN, kuma sun tabbatar ta hanyar gwaje-gwajen cewa NMN na iya rage yawan ƙwayoyin ƙwayoyin cuta da ke da alaka da ƙwayoyin cuta da kuma abubuwan da ke faruwa na rayuwa, da kuma hana amsawar macrophages.Iyaka a cikin Ilimin Halittar Halitta .

Kumburi yana canza matakan abubuwan da ke faruwa a cikin macrophages
Na farko, ƙungiyar bincike ta kunna macrophages don samar da kumburi ta hanyar lipopolysaccharide (LPS), sannan kuma sun bincika abubuwan da ke cikin abubuwan da ke kewaye da macrophages yayin kumburi.An haɓaka matakan metabolites 99 kuma an rage metabolites 105 a cikin kwayoyin 458 da aka gano kafin da bayan haɓakar kumburi, kuma matakan NAD + waɗanda ke rakiyar kumburi suma sun ragu.

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NMN yana ƙara matakan NAD kuma yana rage kumburi na macrophage
Ƙungiyar binciken ta bi da macrophages tare da LPS, wanda ke haifar da yanayi mai kumburi, IL-6 da IL-1β, cytokines pro-inflammatory wanda ke aiki a matsayin alamun kumburi.Bayan maganin NMN na kumburin macrophage da LPS ya haifar, an gano cewa matakin NAD na ciki ya karu kuma an rage bayyanar mRNA na IL-6 da IL-1β.Gwaje-gwaje sun nuna cewa NMN ta ƙara matakin NAD da rage kumburin macrophage da ke haifar da LPS.

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NMN yana rage matakan furotin da ke da alaƙa da kumburi
NMN magani, an gano cewa sunadaran da ke da alaƙa da kumburi irin su RELL1, PTGS2, FGA, FGB da igkv12-44 an rage su a cikin sel, wanda ya nuna cewa NMN ya rage bayyanar cututtuka masu alaƙa da kumburi.

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NMN yana rage maganganun NSAIDS sunadaran da ake nufi
Gwajin ƙarshe na ƙarshe ya gano cewa NMN ya rage matakin PGE2 a cikin ƙwayoyin RAW264.7 da aka kunna LPS ta hanyar rage matakin magana na COX-2, ta haka ne rage ma'anar COX2 da hana kumburin LPS.

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Ƙarshe , ƙarin NMN zai iya magance kumburi na kullum a cikin mice, kuma maganin kumburi a cikin mutane har yanzu yana buƙatar tabbatarwa ta hanyar gwaji na asibiti masu dacewa.Watakila NMN zai zama madadin NSAIDS nan gaba kadan.

ambaton:
1.Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H. Nicotinamide Mononucleotide Rage LPS-Induced Inflammation da Oxidative Stress ta hanyar Rage COX-2 Magana a Macrophages.Gaban Mol Biosci.Yuli 6, 2021.