Binciken Express | Binciken Jami'ar Tsinghua ya nuna cewa NMN na iya magance kumburi

Kunna Macrophage wata hanya ce ta cututtuka da ke haifar da kumburi mai ɗorewa a jiki, amma ci gaba da kunna macrophage na iya haifar da kumburi mai ɗorewa da cututtuka kamar juriya ga insulin da cututtuka masu tsanani kamar atherosclerosis. PGE 2, wanda ke shiga tsakani kan amsawar kumburi, an haɗa shi daga arachidonic acid ta hanyar cyclooxygenases (COX-1 da COX-2). COX-1 da COX-2 sune manyan abubuwan da ke haifar da kumburi kuma ana iya hana su ta hanyar magungunan hana kumburi marasa steroidal (NSAIDs).

Amfani da NSAIDs na iya haifar da sakamako masu illa da yawa, kamar zubar jini a cikin hanji. Saboda haka, yana da mahimmanci musamman a sami wani abu na halitta mafi aminci don magance kumburi.

Kwanan nan, wata ƙungiyar bincike daga Jami'ar Tsinghua ta yi wa ƙwayoyin halittar beraye magani da NMN, kuma ta hanyar gwaje-gwajen da aka gudanar ta tabbatar da cewa NMN na iya rage tarin sunadaran da ke da alaƙa da kumburi da kuma abubuwan da ke haifar da metabolism, da kuma hana amsawar kumburi na ƙwayoyin halittar macrophages. Iyakoki a Kimiyyar Halittu ta Kwayar Halitta.

Kumburi yana canza matakan abubuwan da ke cikin macrophages na rayuwa.
Da farko, ƙungiyar binciken ta kunna macrophages don samar da kumburi ta hanyar lipopolysaccharide (LPS), sannan ta yi nazarin abubuwan da ke cikin samfuran da ke kewaye da macrophages yayin kumburi. Matakan metabolites 99 sun karu kuma an rage metabolites 105 daga cikin ƙwayoyin halitta 458 da aka gano kafin da kuma bayan motsawar kumburi, kuma matakan NAD+ da ke tare da kumburi suma sun ragu.

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NMN yana ƙara matakan NAD kuma yana rage kumburin macrophage
Daga nan sai ƙungiyar binciken ta yi wa macrophages magani da LPS, wanda ke haifar da yanayin kumburi, IL-6 da IL-1β, cytokines masu hana kumburi waɗanda ke aiki a matsayin alamun kumburi. Bayan maganin NMN na kumburin macrophage da LPS ya haifar, an gano cewa matakin NAD na cikin ƙwayoyin halitta ya ƙaru kuma an rage yawan mRNA na IL-6 da IL-1β. Gwaje-gwaje sun nuna cewa NMN ya ƙara matakin NAD kuma ya rage kumburin macrophage da LPS ya haifar.

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NMN yana rage matakan furotin da ke da alaƙa da kumburi
A lokacin da aka yi amfani da maganin NMN, an gano cewa sunadaran da ke da alaƙa da kumburi kamar RELL1, PTGS2, FGA, FGB da igkv12-44 sun ragu a cikin ƙwayoyin halitta, wanda hakan ya nuna cewa NMN ta rage yawan furotin da ke da alaƙa da kumburi.

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NMN yana rage yawan furotin da NSAIDS ke samarwa
Gwajin ƙarshe ya gano cewa NMN ta rage matakin PGE2 a cikin ƙwayoyin RAW264.7 da LPS ke kunna ta hanyar rage matakin bayyanar COX-2, ta haka ne rage bayyanar COX2 da kuma hana kumburi da LPS ke haifarwa.

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A ƙarshe, ƙarin NMN zai iya magance kumburi mai ɗorewa a cikin beraye yadda ya kamata, kuma maganin kumburi a cikin mutane har yanzu yana buƙatar a tabbatar da shi ta hanyar gwaje-gwajen asibiti masu dacewa. Wataƙila NMN zai zama madadin NSAIDS nan gaba kaɗan.

nassoshi:
1.Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H. Nicotinamide Mononucleotide Rage LPS-Induced Inflammation da Oxidative Stress ta hanyar Rage COX-2 Magana a Macrophages. Gaban Mol Biosci. 6 ga Yuli 2021.