Imine reductase (IRED)
Takaitaccen Bayani:
Game da Imine reductase
ES-IRED: Wani nau'in enzymes wanda ke haifar da raguwar haɗin C=N zuwa CN bond.Nasa ne na redox enzyme, tare da coenzyme NADPH don jigilar hydrogen.Dangane da fifikon chiral na samfuran, ana iya raba su zuwa R-IRED da S-IRED.Syncozymes sun haɓaka 15 imine reductases (lambobin ES-IRED-101-ES-IRED-115), waɗanda za a iya amfani da su sosai a cikin zaɓin regiosective da stereoselective na imines don shirya amines na chiral.
Nau'in amsawar catalytic:
Wayar hannu/Wechat/WhatsApp: +86-13681683526
Imel:lchen@syncozymes.com
| Enzymes | Lambar samfur | Ƙayyadaddun bayanai |
| Enzyme Foda | ES-IRED-101~ ES-IRED-114 | saitin 14 Imine Reductase, 50 MG kowace |
| 96-To Enzyme Screening Kit | Saukewa: ES-1400 | saitin 14 Imine Reductase, 1 MG kowace |
★ High substrate takamaiman.
★ Karfin chiral selectivity.
★ Babban juzu'i.
★ Kadan kayan masarufi.
★ Sharuɗɗan ɗaukar hankali.
★ Abokan Muhalli.
➢ Yawanci, tsarin amsawa yakamata ya haɗa da substrate, maganin buffer, enzyme, coenzyme, da tsarin farfadowa na coenzyme.
➢ Duk nau'ikan ES-IREDs masu dacewa da yanayi daban-daban masu inganci yakamata a yi nazari akai-akai.
➢ Babban abun da ke ciki ko samfur mai iya hana ayyukan ES-IRED.Duk da haka, ana iya samun sauƙin hanawa ta hanyar ƙari na substrate.
Misali 1 (Biosynthesis na chiral 2-methyl pyrrolidine)(1):
Misali 2 (Biosynthesis of secondary amine)(2):
Misali na 3 (Rage Imines na Cyclic)(3):
Ci gaba da shekaru 2 ƙasa -20 ℃.
Kada a taɓa hulɗa da matsananciyar yanayi kamar: babban zafin jiki, high / low pH da babban taro kwayoyin kaushi.
1. Scheller PN, Fademrecht S, Hofelzer S, et al.ChemBioChem, 2014, 15, 2201-2204.
2. Wetzl D, Gand M, Ross A, et al.ChemCatChem, 2016, 8, 2023-2026.
3. Li H, Luan ZJ, Zheng GW, et al.Adv.Synth.Katal.2015, 357, 1692-1696.
