Imine reductase (IRED)
Takaitaccen Bayani:
Game da Imine reductase
ES-IRED: Wani nau'in enzymes ne da ke haɓaka rage haɗin C=N zuwa haɗin CN. Yana cikin redox enzyme, tare da coenzyme NADPH don jigilar hydrogen. Dangane da fifikon chiral na samfuran, ana iya raba su zuwa R-IRED da S-IRED. Syncozymes sun haɓaka reductases 15 na imine (numbIRED ES-IRED-101-ES-IRED-115), wanda za'a iya amfani dashi sosai a cikin rage regioselective da stereoselective na imines don shirya chiral amines.
Nau'in amsawar catalytic:
Wayar Salula/Wechat/WhatsApp: +86-13681683526
Imel:lchen@syncozymes.com
| Enzymes | Lambar Samfura | Ƙayyadewa |
| Foda na Enzyme | ES-IRED-101~ ES-IRED-114 | saitin Imine Reductase 14, 50 MG kowanne |
| Kayan Aikin Nuna Enzyme na Well 96 | ES-IRED-1400 | saitin Imine Reductase 14, 1 MG kowanne |
★ Babban takamaiman substrate.
★ Ƙarfin zaɓin chiral.
★ Babban canji.
★ Rage yawan kayayyakin da aka samar.
★ Yanayin amsawa mai sauƙi.
★ Mai kyau ga muhalli.
➢ A al'ada, tsarin amsawar yakamata ya haɗa da substrate, maganin buffer, enzyme, coenzyme, da tsarin sake farfaɗo da coenzyme.
➢ Ya kamata a yi nazarin dukkan nau'ikan ES-IREDs da suka dace da yanayin amsawar da ya dace daban-daban.
➢ Yawan sinadarin substrate ko samfurin da ke ɗauke da shi na iya hana ayyukan ES-IRED. Duk da haka, ana iya rage toshewar ta hanyar ƙara substrate a cikin rukuni.
Misali na 1(Biosynthesis na chiral 2-methyl pyrrolidine)(1):
Misali na 2 (Biosynthesis na amine na biyu)(2):
Misali na 3 (Rage Rage Ra'ayoyin Masu Zagaye)(3):
Ajiye shi a wuri mai sanyi na tsawon shekaru 2 ƙasa da -20 ℃.
Kada a taɓa yin hulɗa da yanayi mai tsanani kamar: zafin jiki mai yawa, pH mai yawa/ƙaranci da kuma yawan sinadarin sinadarai masu narkewa.
1. Scheller PN, Fademrecht S, Hofelzer S, et al. ChemBioChem, 2014, 15, 2201-2204.
2. Wetzl D, Gand M, Ross A, da sauransu. ChemCatChem, 2016, 8, 2023-2026.
3. Li H, Luan ZJ, Zheng GW, et al. Adv. Synth. Katal. 2015, 357, 1692-1696.
