Oxynitrilases (HNL)
Takaitaccen Bayani:
Game da oxynitrilases
ES-HNLs: Wani nau'in enzyme na aji wanda ke ba da damar ƙara HCN zuwa aldehydes (ketones) don samun nau'in cyanide na nau'in R ko S, wanda za'a iya canzawa cikin sauƙi zuwa nau'ikan magunguna ko tsaka-tsakin magunguna ta hanyar sinadarai.
Akwai nau'ikan samfuran oxynitrilase guda 29 (Lambar kamar ES-HNL-101-ES-HNL-129) wanda SyncoZymes ya haɓaka.SZ-HNL kayan aiki ne mai amfani ga regio- da stereo-zabi kira na (R) -cyanohydrins ko (S) -cyanohydrins daga nau'ikan aromatic, aliphatic da heterocyclic aldehydes ko ma ketones.
Nau'in amsawar catalytic:
Wayar hannu/Wechat/WhatsApp: +86-13681683526
Imel:lchen@syncozymes.com
| Enzymes | Lambar samfur | Ƙayyadaddun bayanai |
| Enzyme Foda | ES-HNL-101~ ES-HNL-129 | saitin 29 oxynitrilases, 50 MG kowane 29 abubuwa * 50mg / abu, ko wani adadi |
| Kit ɗin Nuna (SynKit) | Saukewa: ES-HNL-1800 | saitin 18 (S) -oxynitrilases, 1 MG kowane 18 abubuwa * 1 MG / abu |
| Kit ɗin Nuna (SynKit) | Saukewa: ES-HNL-1100 | saitin 11 (R) -oxynitrilases, 1 MG kowane 11 abu * 1 MG / abu |
★ High substrate takamaiman.
★ Karfin chiral selectivity.
★ Babban juzu'i.
★ Kadan kayan masarufi.
★ Sharuɗɗan ɗaukar hankali.
★ Abokan Muhalli.
➢ Yawanci, tsarin amsawa yakamata ya haɗa da substrate (aldehydes / ketones, HCN), maganin buffer (pH mafi kyawun amsawa) da enzymes.
➢ Ana iya gwada duk ES-HNLs bi da bi a cikin tsarin amsawa a sama ko tare da Kit ɗin Screening HNL (SynKit HNL).
➢ Duk nau'ikan ES-HNL da suka dace da yanayin amsawa daban-daban yakamata a yi nazari akai-akai.
➢ Babban abun da ke ciki ko samfur mai iya hana ayyukan ES-HNL.Duk da haka, ana iya sauƙaƙe hanawa ta hanyar ƙara nau'i na substrate.
Misali 1(1):
Ci gaba da shekaru 2 ƙasa -20 ℃.
Kada a taɓa hulɗa da matsananciyar yanayi kamar: babban zafin jiki, high / low pH da babban taro kwayoyin kaushi.
1 Langermann J, Guterl JK, Pohl M, da tal.Bioprocess Biosyst Eng, 2008, 31: 155-161.
