Amine Dehydrogenase (AmDH)
Takaitaccen Bayani:
Game da Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): wani enzyme wanda zai iya haifar da ammonium na ƙungiyar carbonyl kuma ya rage shi zuwa rukunin amino.Yana da coenzyme NADH wanda ya dogara da enzyme, kuma NADH yana aiki azaman mai watsa hydrogen.Akwai nau'ikan samfuran enzyme AmDH guda 4 (Lamba kamar ES-AmDH101～ES-AmDH104) wanda SyncoZymes ya haɓaka, waɗanda za'a iya amfani da su a cikin zaɓin regiosective ko stereoselective reductive amination na aldehydes da ketones.
Nau'in amsawar catalytic:
Wayar hannu/Wechat/WhatsApp: +86-13681683526
Imel:lchen@syncozymes.com
★ High substrate takamaiman.
★ Karfin chiral selectivity.
★ Babban juzu'i.
★ Kadan kayan masarufi.
★ Sharuɗɗan ɗaukar hankali.
★ Abokan Muhalli.
➢ Yawanci, tsarin amsawa yakamata ya haɗa da substrate, maganin buffer, enzyme, coenzyme da tsarin farfadowa na coenzyme (misali glucose da glucose dehydrogenase).
➢ AmDH ya kamata a ƙara ƙarshe zuwa tsarin amsawa, bayan an daidaita pH da zafin jiki zuwa yanayin amsawa.
Misali na 1 (Hadarin madaidaicin amines na chiral ta hanyar rage amination na alkyl aryl ketones)(1):
Ci gaba da shekaru 2 ƙasa -20 ℃.
Kada a taɓa hulɗa da matsananciyar yanayi kamar: babban zafin jiki, high / low pH da babban taro kwayoyin kaushi.
1. Kong W, Liu Y, Huang C, et al.Angewandte Chemie International Edition, 2022: e202202264.
