Amine Dehydrogenase (AmDH)
Takaitaccen Bayani:
Game da Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): wani enzyme ne wanda zai iya haɓaka ammonia na ƙungiyar carbonyl kuma ya rage shi zuwa rukunin amino. Enzyme ne mai dogaro da coenzyme NADH, kuma NADH yana aiki azaman mai watsa hydrogen. Akwai nau'ikan samfuran enzyme na AmDH guda 4 (Lambar kamar ES-AmDH101～ES-AmDH104) waɗanda SyncoZymes suka ƙirƙira, waɗanda za a iya amfani da su wajen haɗa aldehydes da ketones a cikin regioselective ko stereoselective reductive amination.
Nau'in amsawar catalytic:
Wayar Salula/Wechat/WhatsApp: +86-13681683526
Imel:lchen@syncozymes.com
★ Babban takamaiman substrate.
★ Ƙarfin zaɓin chiral.
★ Babban canji.
★ Rage yawan kayayyakin da aka samar.
★ Yanayin amsawa mai sauƙi.
★ Mai kyau ga muhalli.
➢ A al'ada, tsarin amsawar yakamata ya haɗa da substrate, maganin buffer, enzyme, coenzyme da tsarin sake farfaɗo da coenzyme (misali glucose da glucose dehydrogenase).
➢ Ya kamata a ƙara AmDH a ƙarshe a cikin tsarin amsawa, bayan an daidaita pH da zafin jiki zuwa yanayin amsawar.
Misali na 1 (Haɗar amines na chiral ta hanyar rage yawan alkyl aryl ketones)(1):
Ajiye shi a wuri mai sanyi na tsawon shekaru 2 ƙasa da -20 ℃.
Kada a taɓa yin hulɗa da yanayi mai tsanani kamar: zafin jiki mai yawa, pH mai yawa/ƙaranci da kuma yawan sinadarin sinadarai masu narkewa.
1. Kong W, Liu Y, Huang C, et al. Angewandte Chemie International Edition, 2022: e202202264.
